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KMID : 0644120110240010015
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Journal of Oriental Gynecology
2011 Volume.24 No. 1 p.15 ~ p.26
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The anti-inflammatory effects of Cicadidae Periostracum
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Kim Kyoung-Wan
Cho Han-Baek
Kim Song-Baek
Choe Chang-Min
Seo Yun-Jung
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Abstract
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Objectives: The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Cicadidae Periostracum(CP) on the RAW 264.7 cells.
Method: We examined the cytokine productions including nitric oxide(NO), interleukin(IL)-1b, IL-6 and tumor necrosis factor-a(TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen -activated protein kinases(MAPKs) and nuclear factor kappa BNF-kB) using Western blot.
Results: CP inhibited LPS-induced production of NO, IL-1b and TNF-a but not of IL-6 in RAW 264.7 cells. CP respectively inhibited the activation of MAPKs such as extracelluar signal-regulated kinase(ERK 1/2), c-Jun -terminal kinase(JNK), p38 and NF-kB in the LPS-stimulated RAW 264.7 cells. Also oral administration of CP inhibited CLP - induced endotoxin shock.
Conclusion: our results showed that CP down-regulated LPS-induced NO, IL-1b and TNF-a productions mainly through ERK, JNK, p38 MAPK and NF-kB pathway, which suggest the anti-inflammatory effects of CP.
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KEYWORD
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Crytotympana pustulata(CP), lipopolysaccharide(LPS), Inflammation, Cytokine
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